📄 Category

pharmacology and therapeutics

24 papers

Pharmacology and therapeutics sits at the exciting intersection where chemical compounds meet human health, focusing on how medicines work within the body and how they can best be used to treat disease. This field explores everything from the initial discovery of new drug molecules to understanding their safety, dosage, and real-world effectiveness in diverse patient populations. It is the science of turning laboratory findings into practical treatments that improve lives.

On Gist.Science, we bridge the gap between rapid scientific discovery and public understanding by curating the latest preprints from medRxiv dedicated to this vital area. Our team processes every new submission in this category, transforming complex research into both accessible plain-language explanations and detailed technical summaries. This ensures that whether you are a researcher or a curious reader, you can grasp the nuances of emerging therapies without getting lost in dense jargon.

Below are the most recent pharmacology and therapeutics papers from medRxiv, ready for you to explore.

📄 pharmacology and therapeutics

Exploring Ensemble Selection for Model Averaging in Model-informed Precision Dosing: A Tacrolimus Case Study Extended to Cefepime and InfliximabExploring Ensemble Selection for Model Averaging in Model-informed Precision Dosing: A Tacrolimus Case Study Extended to Cefepime and Infliximab

This study demonstrates that for model-informed precision dosing of tacrolimus, cefepime, and infliximab, carefully selecting a small, well-chosen ensemble of population pharmacokinetic models based on specific observation sets yields superior predictive performance compared to using all available models or relying solely on ensemble size.

Baroudi, S., Franck, B., Woillard, J.-B., Destere, A., Comets, E., LEMAITRE, F.2026-10-02
📄 pharmacology and therapeutics

Varenicline as a Repurposable Drug Candidate for ADRD Prevention

Using the All of Us Research Database, this study found that among older adults initiating smoking cessation therapy, varenicline use was associated with a significantly reduced risk of Alzheimer's disease and related dementias compared to nicotine replacement therapy, supporting its potential as a repurposable drug for ADRD prevention.

Ma, P., Zhou, J., Cheng, Y., McGeary, J. E., Taveira, T. H., Ahmed, A., Wu, W.-C., Zamrini, E., Dugger, B. N., Sevilla (…)2026-09-20
📄 pharmacology and therapeutics

Clofazimine pharmacokinetics in novel rifampicin-resistant tuberculosis regimens: an analysis of the endTB and endTB-Q trials

This analysis of the endTB and endTB-Q trials characterizes clofazimine pharmacokinetics in rifampicin-resistant tuberculosis patients, revealing that delamanid co-administration, diabetes, and HIV significantly alter drug exposure and that the drug persists in the body for over two years following a nine-month treatment course.

Ngara, B., P.Solans, B., Yang, E., Van Brantegem, P., Guglielmetti, L., Varaine, F., Gouillou, M., Mitnick, C. D., LaHoo (…)2026-09-20
📄 pharmacology and therapeutics

Impact of Polypharmacy on Medication Adherence in Patients with Comorbid Type 2 Diabetes and Hypertension in Tanzania: A Cross-Sectional Study

This cross-sectional study of 396 outpatients at Muhimbili National Hospital in Tanzania reveals a high prevalence of polypharmacy (71%) and suboptimal medication adherence (55.1%) among patients with comorbid Type 2 diabetes and hypertension, identifying factors such as elevated glucose levels, herbal medicine use, and uncontrolled blood pressure as significant barriers to adherence.

Kihombo, F. B., Ilomo, H., Manguzu, M. A., Marealle, A. I., Mutagonda, R. F.2026-08-17
📄 pharmacology and therapeutics

Diversity and Utilization Patterns of Medicinal Plants Used in the Management of Diabetes Mellitus: An Ethnobotanical Study in Selected Communities in Sierra Leone

This ethnobotanical study in Sierra Leone documents 21 medicinal plant species used for managing diabetes, highlighting a high level of community consensus on specific species like *Moringa oleifera* and *Vernonia amygdalina* and underscoring the need for further pharmacological research and sustainable preservation of this traditional knowledge.

Kamara, S., Jimmy, A. I., Gary, L. P.2026-07-21
📄 pharmacology and therapeutics

Pre-Operative Single 150 Mg Dose of Pregabalin for Postoperative Pain Management in Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis of seven randomized controlled trials demonstrates that a single preoperative 150 mg dose of pregabalin significantly reduces postoperative pain and opioid consumption while maintaining an acceptable safety profile in patients undergoing laparoscopic cholecystectomy.

Dewasi, G., Nagda, P., Jain, S.2026-07-13
📄 pharmacology and therapeutics

SonoPatch: Wearable Sonophoresis for On-Demand Physiological Modulation

This paper introduces "SonoPatch," a wearable sonophoresis device that delivers psychoactive substances transdermally to programmatically modulate user physiology, with a double-blinded study demonstrating its ability to induce significant, on-demand cardiovascular changes consistent with caffeine delivery during both rest and cognitive tasks.

Shimizu, K., Whitmore, N. W., Hossen, A., Zhang, Y., Maes, P.2026-07-07
📄 pharmacology and therapeutics

The Effects of Cognitive Behavioral Therapy for Insomnia on Cardiovascular and Immunological Outcomes: A Randomized-Controlled Study

This randomized-controlled trial found that Cognitive Behavioral Therapy for Insomnia (CBTi) did not produce significant detectable changes in cardiovascular or immunological biomarkers among individuals with insomnia disorder.

Reyt, M., Jarrin, D. C., Perrault, A. A., Borgetto, F., Smith, D., Gong, K., Tarelli, L., Savard, J., Dang-Vu, T. T., Go (…)2026-07-02
📄 pharmacology and therapeutics

Efficacy inference in early-phase non-controlled clinical trials via Bayesian biomarker deconvolution

This paper presents a Bayesian deconvolution framework that separates tissue injury kinetics from biomarker clearance in small, uncontrolled early-phase clinical trials, significantly improving the detection of treatment effects and enabling more efficient dose selection and trial design for acute organ injuries.

Humphries, C., Kilpatrick, A. M., Cartwright, J. A., Potter, C., Fernando, A. J., Candela, M. E., Man, J., Aird, R., Sim (…)2026-06-29